John Hussey was born in Sleaford, Lincolnshire, and was the son of Sir William Hussey (1443-1495), Chief Justice of the King’s Bench. He was first knighted in 1497 at the Battle of Blackheath and was subsequently promoted to Knight Banneret by Henry VIII at Tournai on 16 August 1513, following a string of other appointments, including Sheriff of Lincolnshire (1493); Comptroller of the Household (1509); and custos rotulorum (1513).
Hussey served as Chief Butler of England from 1521 until his death in 1536/7. He was also Chamberlain to King Henry VIII’s daughter, Mary I of England, and a member of the House of Lords. He was elected as a knight of the shire for Lincolnshire and as Member of Parliament on 6 July 1523. In 1529, he was created Lord Hussey of Sleaford by King Henry VIII.
Hussey was implicated in the 1536 Pilgrimage of Grace and accused of conspiracy against the king. Tried on the charge of treason, he was found guilty by the House of Lords and executed at Lincoln in 1536.