Henry Stafford, 2nd Duke of Buckingham, was the nephew of Henry Stafford and Lady Margaret Beaufort, the eldest son of Henry Stafford’s brother, Humphrey Stafford. Following the death of his father in 1458, he became a ward of King Edward IV of England and was appointed Duke of Buckingham in 1460, after the death of his grandfather, the 1st Duke of Buckingham. In 1466, Stafford was married to Catherine Woodville (c.1458-1497), the sister of Edward IV’s queen, Elizabeth Woodville. Together, they had four children.
In the months following Edward IV’s death in 1483, Stafford initially appeared to back the succession of Richard, Duke of Gloucester, to the throne as Richard III of England. But quickly disillusioned with Richard, Stafford switched allegiance to his cousin, Henry Tudor, and mounted a rebellion against Richard in Tudor’s name. The rebellion was unsuccessful and Stafford was executed for treason at Salisbury in November 1483.